COVID19 PlasmaTherapy - Donor Eligibility Pre-Requisites

PlasmaTherapy has recently got some encouraging results and is an emerging therapy for Mild and Moderate symptom patients. 

Finding Plasma Donor is a difficult task as there are certain eligibility criteria as listed below on a high level, detailed description for plasma donor is also listed deep down in this post. 

High-Level details for PlasmaDonation is as below -- 

1. More than 14-days are passed since the negative report of Corona.
2. Donor must had some symptoms of Corona like Fever, Cold, Cough, Diarrhoea etc. Asymptomatic patients plasma is not useful due to weak antibodies.
3. A Donor can donate twice a month within the interval of 15-days.
4. Antibodies remain present in eligible donor till 4 months of the duration since the negative report of the Corona. So eligible till 4 months.
5. Diabetic donor should be having the diabetes under control and be on medicine, diabetic donor on Insulin is not eligible for Plasma Donation.

Following Documents are needed from the donor side -

1. Corona +ve test report + at-least 14days old Corona -ve test report.
2. If you don't have these reports, then get the "COVID Antibody IgM and IgG" testing done by a lab as explained here  + Current COVID -ve test reports 

FACTS:

1. AB is the universal blood type for plasma donations, 
2. A normal person can donate after 24 hours if plasma protein is more than 6 gm, ICMR has a 14 days guideline being followed by Hospitals or Blood Transfusion Centres.
3. Plasma Extraction could be done at any BloodBank having the required setup for transfusion. 

PLASMA COMPATIBILITY CHART:

FULL DETAILS OF THE PRE-REQUISITE:

Following pre-donation tests as required for Convalescent Plasmapheresis:

1. Blood group (ABO grouping and Rh phenotyping) and antibody screening for clinically significant antibodies (Extended Rh, Kell, Duffy, Kidd, MNS) – Antibody screen positive donors will be deferred. 
2. Complete blood count including Hb, Hct, Platelet count, Total and differential leucocyte count. Donors with Hb>12.5g/dl, platelet count >1,50,000 per microliter of blood and TLC within normal limits will be accepted. 
3. Screening for HIV, HBV and HCV by serology or NAT. Donor negative by either test will be included. Screening for syphilis and malaria by serology. Negative donors will be included. 
4. Total serum protein. Donors with total serum protein > 6gm/dl will be accepted 
5. Presence of IgG and IgM antibodies to COVID-19 (Desired titers for IgG antibodies are 1:1024 as per ICMR, IgG titer (against S-protein RBD) above 1:640 as per off label). Donors negative for these will be deferred.